- Original Article
- Apoptosis and upregulation of TNF-α and TRAIL receptor 1 (DR4)
in the pathogenesis of food protein-induced enterocolitis syndrome
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Jin-Bok Hwang, Sang Pyo Kim, Yu Na Kang, Seong-Ryong Lee, Seong-Il Suh, Taeg Kyu Kwon
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Clin Exp Pediatr. 2010;53(4):525-531. Published online April 15, 2010
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Purpose : Expression levels of tumor necrosis factor (TNF)-α expression on the mucosa of the small intestine is increased
in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES). TNF-α has been reported to induce
apoptotic cell death in the epithelial cells. We studied the TNF family and TNF-receptor family apoptosis on the duodenal
mucosa to investigate their roles in the pathogenesis... |
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